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1

Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types

Klutchko, Sylvester, Blankley, C. John, Fleming, Robert W., Hinkley, Jack M., Werner, Ann E., Nordin, Ivan, Holmes, Ann, Hoefle, Milton L., Cohen, David M.

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 1.13 MB

english, 1986

2

ChemInform Abstract: Synthesis and Structure-Activity Relationships of 9-Substituted Acridines as Endothelin-A Receptor Antagonists.

X.-M. CHENG, C. LEE, S. KLUTCHKO, T. WINTERS, E. E. REYNOLDS, K. M. WELCH, M. A. FLYNN, A. M. DOHERTY

Journal:

Year:

1997

File:

PDF, 27 KB

1997

3

ChemInform Abstract: Benzofuran Derivatives as ETA-Selective, Non-Peptide Endothelin Antagonists.

J. S. KALTENBRONN, J. III QUIN, B. R. REISDORPH, S. KLUTCHKO, E. E. REYNOLDS, K. M. WELCH, M. A. FLYNN, A. M. DOHERTY

Journal:

Year:

1997

File:

PDF, 33 KB

1997

4

ChemInform Abstract: 2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure—Activity Relationships Against Selected Tyrosine Kinases and in vitro and in vivo Anticancer Activity.

S. R. KLUTCHKO, ET AL. ET AL.

Journal:

Year:

1998

Language:

english

File:

PDF, 38 KB

english, 1998

5

Immunological studies of β-adrenergic receptors

P. O. Couraud, B. Z. Lu, A. Schmutz, O. Durieu-Trautmann, C. Klutchko-Delavier, J. Hoebeke, A. D. Strosberg

Journal:

Journal of Cellular Biochemistry

Year:

1983

Language:

english

File:

PDF, 411 KB

english, 1983

6

Visualization of the turkey erythrocyte β-adrenergic receptor

O. Durieu-Trautmann, C. Delavier-Klutchko, G. Vauquelin, A. D. Strosberg

Journal:

Journal of Cellular Biochemistry

Year:

1980

Language:

english

File:

PDF, 567 KB

english, 1980

7

Benzofuran derivatives as ETA-selective, non-peptide endothelin antagonists

JS Kaltenbronn, J Quin III, BR Reisdorph, S Klutchko, EE Reynolds, KM Welch, MA Flynn, AM Doherty

Journal:

European Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 601 KB

english, 1997

8

Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists

X.-M. Cheng, C. Lee, S. Klutchko, T. Winters, E.E. Reynolds, K.M. Welch, M.A. Flynn, A.M. Doherty

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 241 KB

english, 1996

9

Expression of Human β1 and β2 Adrenergic Receptors in E. Coli As a New Tool for Ligand Screening

Marullo, Stefano, Delavier-Klutchko, Colette, Guillet, Jean-Gérard, Charbit, Alain, Strosberg, Arthur Donny, Jean Emorine, Laurent

Journal:

Year:

1989

File:

PDF, 642 KB

1989

10

Anti-Angiogenic Activity of Selected Receptor Tyrosine Kinase Inhibitors, PD166285 and PD173074: Implications for Combination Treatment with Photodynamic Therapy

Charles J. Dimitroff, Wayne Klohs, Amarnath Sharma, Paula Pera, Denise Driscoll, Jean Veith, Randall Steinkampf, Mel Schroeder, Sylvester Klutchko, Adam Sumlin, Barbara Henderson, Thomas J. Dougherty,

Journal:

Investigational New Drugs

Year:

1999

Language:

english

File:

PDF, 268 KB

english, 1999

11

Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(mercaptomethyl)-2-oxo-1-piperidineacetic acids

Klutchko, Sylvester, Hoefle, Milton L., Smith, Ronald D., Essenburg, Arnold D., Parker, Robert B., Nemeth, Vicki L., Ryan, Michael, Dugan, Deborah H., Kaplan, Harvey R.

Journal:

Journal of Medicinal Chemistry

Year:

1981

Language:

english

File:

PDF, 823 KB

english, 1981

12

2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Klutchko, Sylvester R., Hamby, James M., Boschelli, Diane H., Wu, Zhipei, Kraker, Alan J., Amar, Aneesa M., Hartl, Brian G., Shen, Cynthia, Klohs, Wayne D., Steinkampf, Randall W.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 404 KB

english, 1998

13

ChemInform Abstract: Derivatives of 5-((1-(4′-Carboxybenzyl)imidazolyl)methylidene) hydantoins as Orally Active Angiotensin II Receptor Antagonists.

J. J. EDMUNDS, S. KLUTCHKO, J. M. HAMBY, A. M. BUNKER, C. J. C. CONNOLLY, R. T. WINTERS, J. III QUINN, I. SIRCAR, J. C. HODGES, R. L. PANEK, J. A. KEISER, A. M. DOHERTY

Journal:

Year:

1996

Language:

english

File:

PDF, 33 KB

english, 1996

14

Heterocyclic syntheses with β-ketosulfoxides. II. New syntheses of 4-hydroxyquinolines, quinolones and cinnolinones

M. Von Strandtmann, S. Klutchko, M. P. Cohen, J. Shavel Jr.

Journal:

Journal of Heterocyclic Chemistry

Year:

1972

Language:

english

File:

PDF, 110 KB

english, 1972

15

Heterocyclic syntheses with β-ketosulfoxides. I. New syntheses of chromones, flavones, thioindigo and thioflavones

M. Von Strandtmann, S. Klutchko, M. P. Cohen, J. Shavel Jr.

Journal:

Journal of Heterocyclic Chemistry

Year:

1972

Language:

english

File:

PDF, 112 KB

english, 1972

16

Heterocyclic synthesis with β-ketosulfoxides IV. Synthesis of 3-substituted chromones

S. Klutchko, M. P. Cohen, J. Shavel Jr., M. Von Strandtmann

Journal:

Journal of Heterocyclic Chemistry

Year:

1974

File:

PDF, 492 KB

1974

17

4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids (spinacines)

Sylvester Klutchko, John C. Hodges, C. John Blankley, Norman L. Colbry

Journal:

Journal of Heterocyclic Chemistry

Year:

1991

File:

PDF, 1023 KB

1991

18

Role of a bacterial cystathionine β-cleavage enzyme in disulfide decomposition

Colette Delavier-Klutchko, Martin Flavin

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation

Year:

1965

Language:

english

File:

PDF, 202 KB

english, 1965

19

Role of a bacterial cystathionine β-cleavage enzyme in potassium transport

Colette Delavier-Klutchko, Martin Flavin

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation

Year:

1965

Language:

english

File:

PDF, 217 KB

english, 1965

20

Monoclonal antibodies directed against the human A431 β-adrenergic receptor recognize two major polypeptide chains

Srinivas V. KAVERI, Paulina CERVANTES-OLIVIER, Colette DELAVIER-KLUTCHKO, A. Donny STROSBERG

Journal:

Year:

1987

Language:

english

File:

PDF, 1.18 MB

english, 1987

21

Localization and characterization of three different β-adrenergic receptors expressed in Escherichia coli

Marie-Pierre CHAPOT, Yuval ESHDAT, Stefano MARULLO, Jean-Gérard GUILLET, Alain CHARBIT, A. Donny STROSBERG, Colette DELAVIER-KLUTCHKO

Journal:

Year:

1990

Language:

english

File:

PDF, 1.00 MB

english, 1990

22

Expression of three human β-adrenergic-receptor subtypes in transfected chinese hamster ovary cells

Keri M. TATE, Marie-M. BRIEND-SUTREN, Laurent J. EMORINE, Colette DELAVIER-KLUTCHKO, Stefano MARULLO, A. Donny STROSBERG

Journal:

Year:

1991

Language:

english

File:

PDF, 524 KB

english, 1991

23

Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype

Blankley, C. John, Hodges, John C., Klutchko, Sylvester R., Himmelsbach, Richard J., Chucholowski, Alexander, Connolly, Cleo J., Neergaard, Sandra J., Van Nieuwenhze, Michael S., Sebastian, Alan

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 1.75 MB

english, 1991

24

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Boschelli, Diane H., Wu, Zhipei, Klutchko, Sylvester R., Showalter, H. D. Hollis, Hamby, James M., Lu, Gina H., Major, Terry C., Dahring, Tawny K., Batley, Brian, Panek, Robert L.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 219 KB

english, 1998

25

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

Patt, William C., Hamilton, Harriet W., Taylor, Michael D., Ryan, Michael J., Taylor, David G., Connolly, Cleo J. C., Doherty, Annette M., Klutchko, Sylvester R., Sircar, Ila

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.48 MB

english, 1992

26

Structural basis for functional diversity of β1-, β2- and β3-adrenergic receptors

Laurent J. Emorine, Bruno Feve, Jacques Pairault, Marie-Madeleine Briend-Sutren, Stefano Marullo, Colette Delavier-Klutchko, Donny A. Strosberg

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 882 KB

english, 1991

27

Altered binding properties of β-adrenergic receptors and lack of coupling to adenylate cyclase in P815 mastocytoma cells

Odile Durieu-Trautmann, Colette Delavier-Klutchko, Johan Hoebeke, A. Donny Strosberg

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 527 KB

english, 1985

28

Solubilization of a catecholamine-sensitive guanosine triphosphatase from turkey erythrocyte membranes

Colette Delavier-Klutchko, Odile Durieu-Trautmann, Pierre-Olivier Couraud, Claudine Andre, A.Donny Strosberg

Journal:

Year:

1980

Language:

english

File:

PDF, 281 KB

english, 1980

29

The human carcinoma cell line A431 possesses large numbers of functional β-adrenergic receptors

C. Delavier-Klutchko, J. Hoebeke, A.D. Strosberg

Journal:

Year:

1984

Language:

english

File:

PDF, 458 KB

english, 1984

30

Reactions of carbanions of dimethyl sulfoxide and dimethyl sulfone with isocyanates, isothiocyanates, and other electrophilic reagents. Preparation of .beta.-amido and .beta.-thioamido sulfoxides and sulfones

Von Strandtmann, Maximilian, Klutchko, S., Connor, D., Shavel, John

Journal:

Journal of Organic Chemistry

Year:

1971

Language:

english

File:

PDF, 420 KB

english, 1971

31

Effect of ammonia and glutamine on macromolecule synthesis and breakdown during sporulation of saccharomyces cerevisiae

Odile Durieu-Trautmann, Colette Delavier-Klutchko

Journal:

Biochemical and Biophysical Research Communications

Year:

1977

Language:

english

File:

PDF, 272 KB

english, 1977

32

The β-adrenergic receptor of turkey erythrocyte membranes: Conformational modification by β-adrenergic agonists

S. Bottari, G. Vauquelin, O. Durieu, C. Klutchko, A.D. Strosberg

Journal:

Biochemical and Biophysical Research Communications

Year:

1979

Language:

english

File:

PDF, 468 KB

english, 1979

33

Antibodies raised against β-adrenergic receptors stimulate adenylate cyclase

Pierre-Olivier Couraud, Colette Delavier-Klutchko, Odile Durieu-Trautmann, A.Donny Strosberg

Journal:

Biochemical and Biophysical Research Communications

Year:

1981

Language:

english

File:

PDF, 434 KB

english, 1981

34

Réaction phosphoroclastique du pyruvate par Clostridium saccharobutyricum Mise en évidence de l'intervention d'un cofacteur de nature ptéridique dans la dégradation du pyruvate

Colette Delavier-Klutchko

Journal:

Biochimica et Biophysica Acta

Year:

1963

File:

PDF, 415 KB

1963

35

Tetrahydroisoquinoline derivatives with AT2-specific angiotensin II reception binding inhibitory activity

Sylvester Klutchko, James M. Hamby, John C. Hodges

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 372 KB

english, 1994

36

Biochemical and immunochemical analysis of β-adrenergic receptor adenylate cyclase complexes

A.Donny Strosberg, P.O. Couraud, O. Durieu-Trautmann, C. Delavier-Klutchko

Journal:

Trends in Pharmacological Sciences

Year:

1982

Language:

english

File:

PDF, 547 KB

english, 1982

37

Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4- d ]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors

Klutchko, Sylvester R., Zhou, Hairong, Winters, R. Thomas, Tran, Tuan P., Bridges, Alexander J., Althaus, Irene W., Amato, Danielle M., Elliott, William L., Ellis, Paul A., Meade, Mary Ann, Roberts, B

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 189 KB

english, 2006

38

Base rearrangement of chromone-3-carboxylic esters to 3-acyl-4-hydroxycoumarins

Klutchko, Sylvester, Shavel, John, Von Strandtmann, Maximilian

Journal:

Journal of Organic Chemistry

Year:

1974

Language:

english

File:

PDF, 280 KB

english, 1974

39

4,7-Diazaindole Derivatives

Klutchko, Sylvester, Hansen, H. Victor, Meltzer, Robert I.

Journal:

Journal of Organic Chemistry

Year:

1965

Language:

english

File:

PDF, 569 KB

english, 1965

40

ChemInform Abstract: 4,5,6,7-Tetrahydro-1H-imidazo(4,5-c)pyridine-6-carboxylic Acids (Spinacines).

KLUTCHKO, S., HODGES, J. C., BLANKLEY, C. J., COLBRY, N. L.

Journal:

Year:

2010

File:

PDF, 39 KB

2010

41

Succinic Ester and Amide of Homoserine: Some Spontaneous and Enzymatic Reactions

Flavin, M., Delavier-Klutchko, C., Slaughter, C.

Journal:

Year:

1964

Language:

english

File:

PDF, 750 KB

english, 1964

42

Chemistry and Pharmacology of Monoamine Oxidase Inhibitors: Hydrazine Derivatives

Anderson, Floyd E., Kaminsky, Daniel., Dubnick, Bernard., Klutchko, Sylvester R., Cetenko, Wiaczeslaw A., Gylys, Jonas., Hart, John A.

Journal:

Journal of Medicinal Chemistry

Year:

1962

Language:

english

File:

PDF, 525 KB

english, 1962

43

Molecular characterization of the human beta 3-adrenergic receptor

Emorine, L., Marullo, S, Briend-Sutren, M., Patey, G, Tate, K, Delavier-Klutchko, C, Strosberg, A.

Journal:

Year:

1989

Language:

english

File:

PDF, 953 KB

english, 1989

44

Towards the chemical and functional characterization of the β-adrenergic receptor

Strosberg, A. Donny, Vauquelin, Georges, Durieu-Trautmann, Odile, Delavier-Klutchko, Colette, Bottari, Serge, Andre, Claudine

Journal:

Trends in Biochemical Sciences

Year:

1980

Language:

english

File:

PDF, 494 KB

english, 1980

45

Structure of the Gene for Human β2-adrenergic Receptor: Expression and Promoter Characterization

L. J. Emorine, S. Marullo, C. Delavier-Klutchko, S. V. Kaveri, O. Durieu-Trautmann and A. D. Strosberg

Journal:

Proceedings of the National Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 960 KB

english, 1987

46

Human β2-adrenergic Receptors Expressed in Escherichia coli Membranes Retain Their Pharmacological Properties

Stefano Marullo, Colette Delavier-Klutchko, Yuval Eshdat, A. Donny Strosberg and Laurent Emorine

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 875 KB

english, 1988

47

Cyclization of 3-(o-hydroxyphenyl)hexahydroindole 1-oxides and 4-(o-hydroxyphenyl)pyrroline 1-oxides. Preparation of hydrobenzofuro[3,2-c]indoles and hydrobenzofuro[2,3-c]pyrroles

Klutchko, S., Sonntag, A. C., Von Strandtmann, M., Shavel, J.

Journal:

Journal of Organic Chemistry

Year:

1973

Language:

english

File:

PDF, 414 KB

english, 1973

48

Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists

Edmunds, Jeremy J., Klutchko, Sylvester, Hamby, James M., Bunker, Amy M., Connolly, Cleo J. C., Winters, R. Thomas, Quin, John, Sircar, Ila, Hodges, John C.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.80 MB

english, 1995

49

Reaction of enamines with o-hydroxy-.omega.-nitrostyrenes. Preparation of benzodihydropyans and hexahydroxanthenes and their rearrangement to pyrroline 1-oxides and hexahydroindole 1-oxides

Klutchko, S., Sonntag, A. C., Von Strandtmann, M., Shavel, J.

Journal:

Journal of Organic Chemistry

Year:

1973

Language:

english

File:

PDF, 442 KB

english, 1973

50

Amino Derivatives of Pyrazine N-Oxides 1

Lutz, Wilson B., Lazarus, Sam, Klutchko, Sylvester, Meltzer, Robert I.

Journal:

Journal of Organic Chemistry

Year:

1964

Language:

english

File:

PDF, 439 KB

english, 1964